Soy products such as tofu are high in protein and are an acceptable source of dietary protein.

Numerous human studies report that adding soy protein to the diet can moderately decrease blood levels of total cholesterol and low-density lipoprotein ("bad" cholesterol). Small reductions in triglycerides may also occur, while high-density lipoprotein ("good" cholesterol) does not seem to be significantly altered. Some scientists have proposed that specific components of soybean, such as the isoflavones genistein and daidzein, may be responsible for the cholesterol-lowering properties of soy. However, this has not been clearly demonstrated in research, and remains controversial. It is not known if products containing isolated soy isoflavones have the same effects as regular dietary intake of soy protein. Dietary soy protein has not been proven to affect long-term cardiovascular outcomes such as heart attack or stroke.

Numerous studies report that infants and young children (ages 2 to 36 months) with diarrhea who are fed soy formula experience fewer bowel movements per day and fewer days of diarrhea. This research suggests soy to have benefits over other types of formula, including cow milk-based solutions. The addition of soy fiber to soy formula may increase the effectiveness. Better quality research is needed before a strong recommendation can be made.Parents are advised to speak with a qualified healthcare provider if infants experience prolonged diarrhea, become dehydrated, develop signs of infection such as fever, or experience blood in the stool. A healthcare provider should be consulted for current breastfeeding recommendations, and to suggest long-term formulas with adequate nutritional value.

Soy products containing isoflavones have been studied for the reduction of menopausal symptoms such as hot flashes. The scientific evidence is mixed in this area, with several human trials suggesting reduced number of hot flashes and other menopausal symptoms, but more recent research reporting no benefits. Overall, the scientific evidence does suggest benefits, although better quality studies are needed in this area in order to form a firm conclusion.

Several large population studies have asked women about their eating habits, and reported higher soy intake (such as dietary tofu) to be associated with a decreased risk of developing breast cancer. However, this type of research can only be considered preliminary, because people who choose to eat soy may also partake in other lifestyle decisions that may lower the risk of cancer. These other habits, rather than soy, could theoretically be the cause of the benefits seen in these studies (for example, lower fat intake, more frequent exercise, lack of smoking). Until better research is available, it remains unclear if dietary soy or soy isoflavone supplements increase or decrease the risk of developing breast cancer.

Genistein, an isoflavone found in soy, has been found in laboratory and animal studies to possess anti-cancer effects, such as blocking new blood vessel growth (anti-angiogenesis), acting as a tyrosine kinase inhibitor (a mechanism of many new cancer treatments), or causing cancer cell death (apoptosis). In contrast, genistein has also been reported to increase the growth of pancreas tumor cells in laboratory research. Until reliable human research is available, it remains unclear if dietary soy or soy isoflavone supplements are beneficial, harmful, or neutral in people with various types of cancer.

Dietary soy protein has not been shown to affect long-term cardiovascular outcomes such as heart attack or stroke. Research does suggest cholesterol-lowering effects of dietary soy, which in theory may reduce cardiovascular risk. Soy has also been studied for blood pressure-lowering and blood sugar-reducing properties in people with type 2 diabetes, although the evidence is not definitive in these areas. Further investigation is needed before a recommendation can be made.

A recent study suggests that isoflavone supplementation in postmenopausal women may have favorable effects on cognitive function, particularly verbal memory. Further research is necessary before a firm conclusion can be drawn.

There is not enough scientific evidence to determine if dietary intake of soy affects the risk of developing colon cancer. Study results are mixed and more research is needed before a recommendation can be made.

Due to limited human study, there is not enough evidence to recommend for or against the use of soy as a therapy in preventing Crohn's disease. Further research is needed before a recommendation can be made.

It has been theorized that the presence in soy of "phytoestrogens" (plant-based compounds with weak estrogen-like properties) such as isoflavones may be beneficial to pre-menopausal women with cyclical breast pain. However, due to limited human study, there is not enough evidence to recommend for or against the use of dietary soy protein as a therapy for this condition.

Due to limited human study, there is not enough evidence to recommend for or against the use of soy-polysaccharide/fiber in the treatment of diarrhea. Further research is needed before a recommendation can be made.

There is not enough scientific evidence to determine if dietary intake of soy affects the risk of developing endometrial cancer.

Due to limited human study, there is not enough evidence to recommend for or against the use of soy as a therapy in cholelithiasis. Further research is needed before a recommendation can be made.

Due to limited human study, the effects of dietary soy on blood pressure are not clear. Further research is necessary before any recommendation can be made.

Due to limited human study, there is not enough evidence to recommend for or against the use of soy in the treatment of kidney diseases such as nephrotic syndrome. People with kidney disease should speak to their healthcare provider about recommended amounts of dietary protein, and should bear in mind that soy is a high protein food.

One study of a phytoestrogen combination showed a reduced the number of migraine attacks suffered. Further research is needed before a recommendation can be made.

Due to limited human study, there is not enough evidence to recommend for or against the use of soy for weight reduction. Further research is needed before a recommendation can be made.

It has been theorized that the presence in soy of "phytoestrogens" (plant-based compounds with weak estrogen-like properties) such as isoflavones may increase bone mineral density in post-menopausal women and reduce the risk of fractures. However, most studies have not been well designed or reported. Until better research is available, a firm conclusion cannot be drawn. Individuals at risk for osteoporosis should speak with a qualified healthcare provider about the therapeutic options for increasing bone mineral density.

Preliminary research has examined the effects of dietary soy intake on prostate cancer development in humans, but results have not been conclusive. Better study is needed before a recommendation can be made.

Preliminary study suggests that intake of soy products may be associated with a reduced risk of death from stomach cancer. Further investigation is needed before a conclusion can be drawn.

Several small studies have examined the effects of soy products on blood sugars in people with type 2 ("adult-onset") diabetes. Results are mixed, with some research reporting decreased blood glucose levels, and other trials noting no effects. Overall, research in this area is not well designed or reported, and better information is needed before the effects of soy on blood sugars can be clearly described.