Burdock (Arctium lappa)

 
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Burdock
Burdock

Background

Burdock has historically been used to treat a wide variety of ailments, including arthritis, diabetes, and hair loss. It is a principal herbal ingredient in the popular cancer remedies Essiac (rhubarb, sorrel, slippery elm) and Hoxsey formula (red clover, poke, prickly ash, bloodroot, barberry).

 

Burdock fruit has been found to lower blood sugar in animals, and early human studies have examined burdock root in diabetes. Laboratory and animal studies have explored the use of burdock for bacterial infections, cancer, HIV, and kidney stones. However, there is currently insufficient human evidence regarding the efficacy of burdock for any indication.

 

Synonyms

Akujitsu, anthraxivore, arctii,  Arctium lappa  Linne,  Arctium minus ,  Arctium tomentosa ,  Arctium tomentosum  Mill., Asteraceae (family), bardana, Bardanae radix, bardane, bardane grande (French), beggar's buttons, burdock root, burr, burr seed, chin, clot-burr, clotbur, cocklebur, cockle button, cocklebuttons, Compositae (family), cuckold, daiki kishi, edible burdock, fox's clote, grass burdock, great bur, great burdock, great burdocks, gobo (Japan), Grosse klette (German), happy major, hardock, hare burr, hurrburr, Kletterwurzel (German), lampazo (Spanish), lappola, love leaves, niu bang zi, oil of lappa, personata, Philanthropium, thorny burr, turkey burrseed, woo-bang-ja, wild gobo.

 

Evidence

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

Uses based on scientific evidence Grade*
Diabetes

 

Animal research and initial human studies suggest possible blood sugar lowering effects of burdock root or fruit. However, the available human research has not been well designed, and further study is needed before a clear recommendation can be made. 		C

 

*Key to grades
A: Strong scientific evidence for this use;
B: Good scientific evidence for this use;
C: Unclear scientific evidence for this use;
D: Fair scientific evidence against this use;
F: Strong scientific evidence against this use.

 

Grading rationale

Uses based on tradition or theory
The below uses are based on tradition or scientific theories. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

Abscesses, acne, anorexia nervosa, aphrodisiac, arthritis, bacterial infections, bladder disorders, blood thinner, boils, burns, cancer, canker sores, common cold, cosmetic uses, dandruff, detoxification, diuretic (increasing urine flow), eczema, fever, fungal infections, gout, hair loss, headache, hemorrhoids, hives, HIV, hormonal effects, ichthyosis (skin disorder), impotence, inflammation, kidney diseases, kidney stones, laxative, liver disease, liver protection, lice, back pain, measles, pneumonia, psoriasis, respiratory infections, rheumatoid arthritis, ringworm, sciatica, scurvy, seborrhea (over-activity of sebaceous skin glands), skin disorders, skin moisturizer, sores, sterility, syphilis, tonsillitis, ulcers, urinary tract infections, venereal diseases, warts, wound healing.

Dosing

The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

Adults (18 years and older)
General use (by mouth): No specific dose of burdock has been proven effective or safe, although a range of doses and types of preparations have been used. As a dried root, tablets/capsules, decoctions, tinctures, fluid extract, and root teas are available. Burdock has been used as a diuretic (to increase urine flow), with preparations made from powdered burdock seeds as a yellow product called oil of lappa.

 

Topical (on the skin): Burdock has been used on the skin as a compress or plaster for eczema, psoriasis, baldness, or warts.

 

Children (younger than 18 years)
There is not enough scientific information to recommend the use of burdock in children.

 

Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Allergies
Allergy to burdock may occur in individuals with allergy to members of the Asteraceae/Compositae family, including ragweed, chrysanthemums, marigolds, and daisies. Severe allergic reactions (anaphylaxis) have been associated with burdock. Allergic skin reactions have been associated with the use of burdock plasters on the skin. Caution should be used in patients with allergies or intolerance to pectin since certain parts of the burdock plant contains different levels of pectin complex.

 

Side Effects and Warnings
Based on traditional use, burdock is generally believed to be safe when taken by mouth in recommended doses for short periods of time. Handling the plant or using preparations on the skin (such as plasters) has occasionally been reported to cause allergic skin reactions. Diuretic effects (increasing urine flow) and estrogen-like effects have been reported with oral burdock use in patients with HIV. Although reports of symptoms such as dry mouth and slow heart rate have been noted in people taking burdock products, it is believed that contamination with belladonna may be responsible for these reactions. Contamination may occur during harvesting.

 

In theory, tannins present in burdock may be toxic, although toxicity has not been reported in animal studies. Tannins can cause stomach upset, and in high concentrations may result in kidney or liver damage. Long-term use of tannins may increase the risk of head and neck cancers, although this has not been seen in humans. Based on animal research and limited human study, burdock may cause increases or reductions in blood sugar levels. Caution is advised in patients with diabetes or hypoglycemia, and in those taking drugs, herbs, or supplements that affect blood sugar. Blood sugar levels may need monitoring by a qualified healthcare provider, and medication adjustments might be necessary. In theory, burdock may also cause electrolyte imbalances (for example, changes in potassium or sodium levels in the blood) due to diuretic effects (increased urine flow).

 

Several case reports of burdock root tea poisoning exist along with cases of burdock ophthalmia. There have been several reports of stomatitis present in dogs that have come in contact with burdock, burs, and bristles.

 

Pregnancy & Breastfeeding
Based on animal studies that show components of burdock to cause uterus stimulation, burdock is sometimes recommended to be avoided during pregnancy. Due to limited scientific study, burdock cannot be considered safe during pregnancy or breastfeeding.

 

Interactions

Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

Interactions with Drugs
Based on animal research and limited human study, burdock may either lower or raise blood sugar levels. Caution is advised when using medications that may also affect blood sugar. Patients taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare provider. Medication adjustments may be necessary. Burdock has been associated with diuretic effects (increasing urine flow) in one human report, and in theory may cause excess fluid loss (dehydration) or electrolyte imbalances (for example, changes in potassium or sodium levels in the blood). These effects may be increased when burdock is taken at the same time as diuretic drugs such as chlorothiazide (Diuril®), furosemide (Lasix®), hydrochlorothiazide (HCTZ), or spironolactone (Aldactone®). Based on limited human evidence that is not entirely clear, burdock may have estrogen-like properties, and may act to increase the effects of estrogenic agents including hormone replacement therapies such as Premarin® or birth control pills.

 

Based on animal research, burdock may increase the risk of bleeding when taken with drugs that increase the risk of bleeding (although human research is lacking). Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®). Tinctures of burdock may contain high concentrations of alcohol (ethanol), and may lead to vomiting if used with disulfiram (Antabuse®) or metronidazole (Flagyl®).

 

Interactions with Herbs & Dietary Supplements
Based on animal research and limited human study, burdock may either lower or raise blood sugar levels. Caution is advised when using herbs or supplements that can also alter blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.

 

Burdock has been associated with diuretic effects (increasing urine flow) in one human report, and in theory, may cause excess fluid loss (dehydration) or electrolyte imbalances (for example, changes in potassium or sodium levels in the blood) when used with other diuretic herbs or supplements.

 

Based on animal research, burdock may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of  Ginkgo biloba , fewer cases with garlic, and two cases with saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.